Sept 9, 2012
Many Web Apps created today use a technique called long-polling to download commands from the server to the browser. This means that, at any given time, there needs to be at least two connections to the same server, one for uploads and one for downloads.
With iOS6, it appears that the number of allowed concurrent connections per server has been lowered to one. Being a common practice for these types of web apps, this means that any web application that uses this technique may be affected.
We have filed a bug report with Apple and as of today, its status is "Critical Bug".
November 1, 2012 - Update
With the release of Real Studio 2012r1.2, we have a partial fix for this bug. While server originated events are still not working, projects that only use user triggered events work just fine now.
December 4, 2012 - Update
With the release of Real Studio 2012r2, mobile Safari on iOS now uses the HTML5 EventSource events to get updates from Real Studio web apps. There is a major advantage to this new technology...the browser can change the poll rate based on user activity and network conditions which leads to better battery life. As an added bonus, this also allows the browser to hide the loading indicator!